Leicester City will face Napoli in the Europa League this season, while Celtic, Bayer Leverkusen, and Real Betis will log it out in the group stage draw released by UEFA on Friday.
Napoli, Leicester, Spartak Moscow, and Legia Warsaw will face one another in Group C as they look to do better than their performance last season.
The Foxes almost missed out on the Champions League last season, finishing fifth in the Premier League but winning the FA Cup.
Napoli, who won the UEFA Cup with Diego Maradona in their ranks in 1989, finished fifth in Serie A last season.
Spartak finished second in the Russian Premier League last season and lost to Benfica in the third qualifying round of the Champions League.
The defending champion of Poland, Legia also lost to Dynamo Zagreb in the third qualifying round of the Champions League.
Celtic also failed to qualify for the Champions League under new manager Ange Postecoglou, but they beat AZ Alkmaar in the Netherlands on Thursday to advance to the Europa League group stage.
Their prize is a spot in Group G with former UEFA Cup winners Leverkusen, Betis, and Ferencvaros.
The Hungarian champions were defeated by Young Boys in the Champions League qualifying round. They knocked out Celtic in the Champions League qualifiers last season.
The Rangers, who beat Celtic for the Scottish title last season, will face French giants Lyon, Sparta Prague, and Danish champions Brondby in Group A.
Europa League Draw
West Ham United was England’s other representative in the Istanbul draw, making a rare European appearance after finishing sixth in the Premier League last season.
David Moyes’ side will face two clubs eliminated from the Champions League qualifiers at Dinamo Zagreb and Genk in Belgium, as well as Rapid Vienna in Group H.
This season’s Europa League group stage has been streamlined to have only 32 teams out of the previous 48, following the launch of the new third-tier Europa Conference League.
The final will be played at the Ramon Sanchez Pizjuan Stadium in Seville on May 18.
Villarreal won the title last season, beating Manchester United on penalties in the final in Gdansk, Poland.
The first round of group fixtures will be played on 16 September.
Draw for the 2021/22 UEFA Europa League group stage:
Group A: Lyon (FRA), Rangers (SCO), Sparta Prague (CZE), Brondby (DEN)
Group B: Monaco (FRA), PSV Eindhoven (NED), Real Sociedad (ESP), Sturm Graz (AUT)
Group C: Napoli (ITA), Leicester City (ENG), Spartak Moscow (RUS), Legia Warsaw (POL)
Group D: Olympiakos (GRE), Eintracht Frankfurt (GER), Fenerbahce (TUR), Royal Antwerp (BEL)
Group E: Lazio (ITA), Lokomotiv Moscow (RUS), Marseille (FRA), Galatasaray (TUR)
Group F: Sporting Braga (POR), Red Star Belgrade (SRB), Ludogorets (BUL), Midtjylland (DEN)
Group G: Bayer Leverkusen (GER), Celtic (SCO), Real Betis (ESP), Ferencvaros (HUN)
Group H: Dinamo Zagreb (CRO), Genk (BEL), West Ham United (ENG), Rapid Vienna (AUT)
